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Sunday, April 30, 2006

Limbo: The Madness Between Trigger & Retrieval

The scariest part of an IVF cycle, for me, is the time between trigger and embryo retrieval. There is something very unsettling about having given yourself a shot of HCG, which starts the process of maturing and releasing the eggs. Essentially, within about 38 to 40 hours each of my follicles will have gone **pop** if they aren't first surgically removed. Once this shot has been given, there's no turning back. A process is spun into place. And it's unstoppable. At no other time in an IVF cycle are we more out of control than we are now.

This is where the horror starts.

Let me share with you the madness that is currently mine:
What if Dr. Moustache gets into a car wreck and doesn't make it to the surgery center on time? Or at all?

What if we get into an accident, ourselves, on the way to the surgery center tomorrow morning?

Was I totally certain to do the shot at just the right time? Is today the 29th? Is the time correct? Did we remember to change all of the clocks in the house during the last time change?

What about those few drops of HCG that I wasn't able to get out of the vial? Damn. Did I really need them? (I sucked them out with a second needle. No worries.)

What if he goes in there and none of my eggs come out?

What if he gets my eggs out okay, but none are mature enough to fertilize?

How come I'm not feeling more fullness and pressure in my ovary region like I did last time?

I feel like I'm getting a cold. Is this going to kill my eggs?
It goes on and on. The list is endless. And in the 11th hour, we're also starting to question the soundness of doing ICSI. The CDC data shows a reduction in success of 20.3% when using ICSI for my age category (40-41) when there isn't male factor infertility, and a drop of 23.5% when there IS male factor infertility. [If you visit the CDC links, click the graphs to see the discussion on each of the two graphs.]

This doesn't make sense. Something has to be amiss with the data. ICSI is supposed to help people with male factor infertility get pregnant. Not hurt their chances. A 23.5% drop in success rate is, well, rather significant! I fired off a late night email to Dr. Moustache asking what to make of the data, and also, "What does your data look like?" Skipping ICSI not only might be a wise move in terms of increasing our chances for success, but it would save us something like $1800 on our tab.

I don't think I'd skip assisted hatching, as my eggs ARE 41 years old and the zonas are probably really THICK...but if there was ample data showing it, too, was questionable, I might skip it, too.

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Comments on "Limbo: The Madness Between Trigger & Retrieval"

 

Blogger Donna said ... (12:37 PM) : 

I'm on pins and needles over here too -- no pressure or anything, but we are badly in need of some good news in Bloglandia. I don't understand those ICSI numbers either, I suppose it goes towards the theory that the less you mess with the egg, the better your chances? I'm glad you are so involved in the care you receive, but it does piss me off that you have to be as involved as you are.

 

Blogger Thalia said ... (2:31 PM) : 

Linda I'm sorry I didn't know until your comment this afternoon that you and I were retrieval buddies. Got my fingers crossed for both of us.

 

Blogger Coloratura said ... (4:09 PM) : 

I hope you get a decent answer from Dr. Moustache... the slippery slope of IVF, argh. Hang in there, and there are lots of people rooting for you - me included!

 

Blogger Beth said ... (8:05 PM) : 

Wishing you the best tomorrow - everything is crossed over here.

 

Anonymous statia said ... (9:15 PM) : 

You sound like me during my last cycle.

I'm curious to see what dr. moustache says about the icsi data.

 

Blogger Simran said ... (10:06 PM) : 

This post has been removed by a blog administrator.

 

Blogger Pamplemousse said ... (3:37 AM) : 

Good luck today, Linda!!! I get completely bamboozled by stats as I do not have that kind of brain but ask me to spell them and I am definitely your woman!! Thinking good thoughts for you.

 

Blogger MoMo said ... (6:34 AM) : 

Linda, good luck today. I will be thinking of you! Hope all goes well. In terms of ICSI, all IVFs in my clinic is done via ICSI, they want to get rid of the unknown. Ask your doctor as many questions until you are comfortable. Hugs!

 

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Ultrasound of a 9 week old fetus

Diagnosis:
elevated NKs, NKUs, 3 +APAs (2 borderline), heterozygous for MTHFR A1298C. Slightly low thyroid.

dq-α:
me: 1.1, 4.1
dh: 1.2, 3.1

Low LADs were treated in Mexico and elsewhere with LIT.
Anti-sperm antibodies
Article: LIT and the FDA

No: ANAs, normal TH1/TH2 Cytokine ratio, or x-DNA/Histones.

IF Treatments:
-Clomid #1: Sept 2005
-Clomid #2: Sept 2005
-HSG: Oct 2005
-Lap/Chromo: Oct 2005
-Nat'l IUI: Nov 2005
-IVF #1: Jan 2006, β1=2.0, β2=0.9
-IVF #2: May 2006, β1=<1.0
-Myomectomy (5), salpingectomy (both), & endo removed via lap on 6.6.6
-LIT#1 in Nogales: 6.16.6
-LIT#2: July 2006
-FET #1: Sept 2006, β1=2.48, β2=<2.0
-Dr. Hungarian Dx Oct 2006
-Dr. Hungarian Tx Dec 2006-Mar 2007
-IVF#3: Mar 2007 Canceled myself right before retrieval
-IVF#4: April/May 2007 Canceled due to dominant follicle
-IVF#4: August 2007, β1<2.0
-IVF#5: December 2007

Pre-ET
Feng Shui'd the House
500mg Zithromax starting with stims
4 LIT Treatments
17 Weeks of Humira or Enbrel
30g IVIg CD5 of IVF cycle (day 2 or 3 of stims)
30g IVIg 2 days before transfer
1mg Dexamethazone starting with stims
30mg Lovenox, 2X's/Day
0.0375mg Synthroid
Lexapro
Prenatal
Folguard 2.2 2x's/day
Extra 1g C (Stop at ET)
Extra 1g Calcium
Extra 400mg E (Stop at ET)
Nettle Tea & Capsules
2g Bromelain
Extra D3
Keep BMI<24
4-6g Fish Oil/Day
Baby Aspirin
Eating Loads of Protein!
Nettle Caplets
Femoral Massage (Stop at ET)
Acupuncture (Stop at ET)
TCM Diet: No cold or slippery foods
Immune Friendly Diet: No non-sprouted wheat, sugar, starches. Little fruit.
No nightshades
No caffeine
No coffee, not even decaf
No soy when in cycle
10 days Doxycycline

Day of Transfer
Light activity

Post ET Changes
Visualization
200mg progesterone capsules
Take it easy days 2&3
No sex til beta#1
Cut out egg yolks (contains immunogenic acid)






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