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Friday, August 04, 2006

Endometrial Biopsy Day
Lexapro Day #2

Today's day 2 of my lexapro. I'm on 10mg/day, so a single tablet in the AM. Yesterday I had a bit of nausea on my first day. That took me totally by surprise. Today I haven't had any nausea, but I am wiped out. Exhausted. I think I slept okay, but it IS Friday, trash day, and the noise starts rather early in the AM. So to say that the exhaustion is from the lexapro is a bit premature.

I'm not keen on this whole idea of taking SSRIs in order to boost my uterine lining, but my serotonin levels are low (73 on a scale of 100-225) so it might be good for me to be taking it "just because". However, I do not feel depressed, down, sad. Just the usual frustration of my profession and of being infertile. I tend to be a bit on the manic side, whizzing through projects, being impatient, over analytical, microassessing, etcetera. I think that part of my mania is likely fueled by the low serotonin levels, and I'm a bit worried that I'll lose a big part of my edge in business by taking this stuff. I love to negotiate, argue a point, and if one of the symptoms is "I just just don't give a damn", how am I going to be effective?

Other big thing going on is that at 3:30PM today I am having my endometrial biopsy done at Dr. G's. Today is CD26 for me and apparantly it's the #1 day for me to have my uterine lining snipped out and analyzed for NKU's (uterine natural killer cells). The reasoning behind this test is that I've had endo. Therefore I likely still have some NKU activity going on in the uterus. Treatment for NKU's is Humira or Enbrel. But even if they don't find them, the NKUs that is, they still want me on the Humira or Enbrel because of my past history with endo.

But the problem with the Humira is that it might cause a NK and cytokine flare. My NKs and cytokines are nice and low right now, so if they flare, the things that bring them down are: Humira, and LIT. So more of the same. It kind of begs the questions as to why the heck am I doing the Humira in the first place.

But such is the treatment cycle, and I've got to trust that DB knew what he was doing.

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Comments on "Endometrial Biopsy Day
Lexapro Day #2
"

 

Blogger Marley said ... (6:16 PM) : 

Sounds like to me you are doing Humira no matter what, so why put yourself throught the biopsy? Skip the torture and go right to Humira.
It lowered my NKU's in 1/2!!! I hated that endo. biopsy and it came back NORMAL for me! I was so not normal...........Good Luck, you are my inspiration.

 

Blogger Marley said ... (6:25 PM) : 

BTW Linda, I am the Dr. Moustache patient who wrote the other day. Did you order those extra immune tests through Dr. Moustache or Dr. Beer's office before you went down to Mexico? I am praying for you. We both have a "Death Killer" uterus. Your posts have done wonders to help me heal since my negative beta last weekend. I think I may look into adoption for now. My future genetic children are on ice in CA w/ Dr. Z right now......Marley

 

Blogger linda said ... (8:51 PM) : 

Hi Marley,

Thanks for stopping by and saying hello.

I did the biopsy today, so it's too late. It hurt pretty bad. She took two samples "just in case". She's a good ob/gyn. She didn't want me to have to go through it a second time. I figured it was good for me to know what I was up against, and that is why I opted for the biopsy.

If the results comes back with horrific numbers of NKUs, it will cement my decision to do my FET in September, rather than August. Having four shots of Humira in my system, rather than two, will really give me a chance then. The only problem is getting my hands on another two shots of humira (or enbrel). I'm working on that though.

It's hard to imagine that the good doctor didn't put a hole through my uterus with that biopsy needle. Ohmygod. I never want to go through that again.

I ordered a bunch of tests on my own after my last IVF failed. I was distraught over our second loss. I wanted answers and I was mad that Dr. Moustache hadn't ordered these tests from the gitgo.

I grabbed a labslip at DB's and filled it out, wrote Dr. Moustache's name on the top as the referring doctor. He wasn't too happy about that, but I got my tests that way. There were a few I missed though: serotonin, free insulin, and a couple of others. But Dr. S filled in the rest of the tests for me.

Ours are on ice with Dr. Moustache, too. I am so afraid for them. Our last babies. It breaks my heart to think of putting them in my toxic uterus. I wish I had the money for a surrogate.

I'm also considering adoption, but my DH, "J", feels we should just try to live a happy childless life if we can't have a child of our own. I love and appreciate him like mad for not inflicting guilt on me for not being able to give him children. But I still feel guilt. I'm wracked with it.

I'm really torn over this idea of adoption. I was adopted, myself, so I know how hard it is to be an adopted child. I think it would make me a good parent of an adopted child, but I think my heart would break more than other parents. I know that when a child discovers that they are adopted that there is a lot of pain. Even if they know all along, there is pain. I was in the latter category, myself.

I hope you'll stop by again!

 

Blogger Millie said ... (1:09 PM) : 

I was going to say I wanted to wish you well on your biopsy--but I saw that it hurt a lot. I'm so sorry.

I'd love to hear more about seratonin and uterine lining. I'm not familiar with that research and have a couple of friends with really severe lining issues. Is there somewhere you can point me?

As for adopting, I think everyone has such different experiences. I have friends who were adopted and say, for them, it was not a big deal. I'm sure this might not be typical but I can only go by what they tell me.

I think things have also changed so much in the last few decades. There are more options (open adoption and more information) and more knowledge.

I also think, for us, that it's become much more about parenting and that's just not something we can give up. I recently read Adopting after Infertility and she talks about the various losses you experience, it's not just one. That part really resonated.

I think you'd be a great parent, however that came about.

Anyway, I hope you're having a good weekend.

 

Blogger Donna said ... (2:02 PM) : 

I hope you are being waited on hand and foot while you recover, sounds like quite an ordeal. All of it, not just the biopsy, that's just the latest thing. I had never heard of the connection between serotonin and thin lining, interesting.

 

Blogger Marley said ... (2:30 PM) : 

Hi Linda,
Dr. Moustache put 3 embryos in and we have 7 on ice. Plus we have 3 blasts on ice here in FL(I did 2 Previous IVF"s here not having a clue about immune issues). Dr. Z said since I just turned 35 he had high hopes. I wanted him to put in 4 but he didn't becuase he felt so sure it would only give us multiples. Yes, I know, who cares about that? I just want a positive test!!!

We have our post-consult on Aug. 12th. He wants me to keep taking Humira. I have one more dose to take on Monday. I am sure he will push for me to fly back out there for a FET.

He also says studies have shown that if I stay on Humira I could get Preg. naturally. I won't hold my breath.

I don't know if I will take anymore Humira after this last dose as it is very $$$$. If you have anymore "good luck" contacts. Let me know.
DR. Moustache's office donated my last shot to me.

We had some tests done already for the infectious diseases before the IVF's. Will those count? My DH has bigtime "White Coat Syndrome" so much so that he used my numbing cream for my PIO shots on his arm when they took blood from him @ Dr. Moustaches's office. I just don't know how much more he can do.

My DH is leaning towards adoption for now and maybe use those embryos later. (after all, in a few years, they will still be 35 year old embryos's right?) I am wondering if I should learn more about my immune issues or get a surrogate?

I am a teacher so my insurance covers nothing unless it is coded as an "Ovarian cyst" or "endo" or something along those lines. I wonder if DB's office would code things as immune issues so my ins. co would recognize it? However, I hope the fact that they are in CA and I am in FL wouldn't affect things?

Thanks for all your info,
Marley
P.S. I tried to email you back but it was returned. Since you emailed me, maybe you could put you email address in so I can write back!!

Sorry about the Biopsy. My experience was AWFUL too. I took a Tylenol #3 before but it didn't kick in until I got home.

 

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Ultrasound of a 9 week old fetus

Diagnosis:
elevated NKs, NKUs, 3 +APAs (2 borderline), heterozygous for MTHFR A1298C. Slightly low thyroid.

dq-α:
me: 1.1, 4.1
dh: 1.2, 3.1

Low LADs were treated in Mexico and elsewhere with LIT.
Anti-sperm antibodies
Article: LIT and the FDA

No: ANAs, normal TH1/TH2 Cytokine ratio, or x-DNA/Histones.

IF Treatments:
-Clomid #1: Sept 2005
-Clomid #2: Sept 2005
-HSG: Oct 2005
-Lap/Chromo: Oct 2005
-Nat'l IUI: Nov 2005
-IVF #1: Jan 2006, β1=2.0, β2=0.9
-IVF #2: May 2006, β1=<1.0
-Myomectomy (5), salpingectomy (both), & endo removed via lap on 6.6.6
-LIT#1 in Nogales: 6.16.6
-LIT#2: July 2006
-FET #1: Sept 2006, β1=2.48, β2=<2.0
-Dr. Hungarian Dx Oct 2006
-Dr. Hungarian Tx Dec 2006-Mar 2007
-IVF#3: Mar 2007 Canceled myself right before retrieval
-IVF#4: April/May 2007 Canceled due to dominant follicle
-IVF#4: August 2007, β1<2.0
-IVF#5: December 2007

Pre-ET
Feng Shui'd the House
500mg Zithromax starting with stims
4 LIT Treatments
17 Weeks of Humira or Enbrel
30g IVIg CD5 of IVF cycle (day 2 or 3 of stims)
30g IVIg 2 days before transfer
1mg Dexamethazone starting with stims
30mg Lovenox, 2X's/Day
0.0375mg Synthroid
Lexapro
Prenatal
Folguard 2.2 2x's/day
Extra 1g C (Stop at ET)
Extra 1g Calcium
Extra 400mg E (Stop at ET)
Nettle Tea & Capsules
2g Bromelain
Extra D3
Keep BMI<24
4-6g Fish Oil/Day
Baby Aspirin
Eating Loads of Protein!
Nettle Caplets
Femoral Massage (Stop at ET)
Acupuncture (Stop at ET)
TCM Diet: No cold or slippery foods
Immune Friendly Diet: No non-sprouted wheat, sugar, starches. Little fruit.
No nightshades
No caffeine
No coffee, not even decaf
No soy when in cycle
10 days Doxycycline

Day of Transfer
Light activity

Post ET Changes
Visualization
200mg progesterone capsules
Take it easy days 2&3
No sex til beta#1
Cut out egg yolks (contains immunogenic acid)






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