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Wednesday, August 08, 2007

Fertilization Report

I went and did an IVIg infusion this morning at 8:15AM. I knew that the RE's office was going to call me to let me know the fertilization report, but I was too nervous to talk to them. By 10AM they still hadn't called so I sent "J" an IM and asked him to call them. I said, "Don't IM me if you talk to them. CALL ME." Nothing could be worse than finding out over IM that your eggs went kaput.

Shortly after I sent that to him, he phoned me. Talk about feeling tense when my phone went off

The first thing out of his mouth was, "It's good news! We got 5!" My heart quickly vacillated between being happy that we had something fertilize and between wondering what happened to the other four.

The breakdown went like this:

  • 1 egg was dead on arrival (probably from the follicle that was 24mm two days before transfer)
  • 1 egg was classified as 3pn (or, three polar nuclei which suggests polyspermy)
  • 2 hadn't yet fertilized as of this morning but they were holding out hope for them
  • 5 fertilized naturally

So we retrieved 9 eggs, 8 were "alive" when the sperm went in, six fertilized, and we are left with 5 embryos. 6/8 = 75% fertilization despite the 3pn one being useless. Ouch. This was our worst cycle yet, but we did ICSI on our previous cycles...so they had a bit of help. I like the idea that "nature" did the picking this time, rather than the embryologist.

I'm still holding out hope that the two stragglers will find themselves fertilized when they take a look tomorrow, but Dr. S did say that eggs tend to be fertilized within the first four hours after the sperm go in. So their chances are looking rather dismal.

I wonder if the two that didn't fertilize where just abnormal? Why don't eggs fertilize? Thick zonas? Yeah. But what are other reasons? "J's" sperm seem to be fine...gosh, we got one egg with polyspermy (ie, the 3pn one) so they are efficient little buggers. So it wasn't the sperm. Something was amiss with the eggs themselves.

Tomorrow we'll get another call from the RE's office as to whether they think we'll be doing a 3 or a 5 day transfer. I was under the impression that we were doing a 3 day transfer on Friday since we only have 5 embryos, but the nurse I spoke with today said that they'll assess their quality tomorrow and will make a final determination at that time.

So we're waiting for more news, yet again.

We're always waiting, aren't we?

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Anonymous Nina said ... (9:23 AM) : 

Firstly congratulations. This is a good fertilizzation report, really good.

Secondly, in our two IVF/ICSI attempts we had a grand total of 24 eggs, non of which fertilized even with ICSI. I often wondered if it was my eggs but since we were dealing with severe MFI we were advised to try with donor sperm instead. Good advise for us since my egg fertilized naturally in the second dIUI.

Thirdly (oh I love my lists), good luck with the rest of the day and week and cycle.

 

Anonymous Pamplemousse said ... (9:24 AM) : 

I am cheering on the Famous Five all the way! Stay cool, lady ;)

 

Blogger Knock Me Up said ... (12:24 PM) : 

Wow, I think it is great that 5 fertilized naturally. That tells you your zona is probably fine and definitely nice to save that $ if you can.

I'll be checking in and hoping all things go well tomorrow.

Merideth

 

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Ultrasound of a 9 week old fetus

Diagnosis:
elevated NKs, NKUs, 3 +APAs (2 borderline), heterozygous for MTHFR A1298C. Slightly low thyroid.

dq-α:
me: 1.1, 4.1
dh: 1.2, 3.1

Low LADs were treated in Mexico and elsewhere with LIT.
Anti-sperm antibodies
Article: LIT and the FDA

No: ANAs, normal TH1/TH2 Cytokine ratio, or x-DNA/Histones.

IF Treatments:
-Clomid #1: Sept 2005
-Clomid #2: Sept 2005
-HSG: Oct 2005
-Lap/Chromo: Oct 2005
-Nat'l IUI: Nov 2005
-IVF #1: Jan 2006, β1=2.0, β2=0.9
-IVF #2: May 2006, β1=<1.0
-Myomectomy (5), salpingectomy (both), & endo removed via lap on 6.6.6
-LIT#1 in Nogales: 6.16.6
-LIT#2: July 2006
-FET #1: Sept 2006, β1=2.48, β2=<2.0
-Dr. Hungarian Dx Oct 2006
-Dr. Hungarian Tx Dec 2006-Mar 2007
-IVF#3: Mar 2007 Canceled myself right before retrieval
-IVF#4: April/May 2007 Canceled due to dominant follicle
-IVF#4: August 2007, β1<2.0
-IVF#5: December 2007

Pre-ET
Feng Shui'd the House
500mg Zithromax starting with stims
4 LIT Treatments
17 Weeks of Humira or Enbrel
30g IVIg CD5 of IVF cycle (day 2 or 3 of stims)
30g IVIg 2 days before transfer
1mg Dexamethazone starting with stims
30mg Lovenox, 2X's/Day
0.0375mg Synthroid
Lexapro
Prenatal
Folguard 2.2 2x's/day
Extra 1g C (Stop at ET)
Extra 1g Calcium
Extra 400mg E (Stop at ET)
Nettle Tea & Capsules
2g Bromelain
Extra D3
Keep BMI<24
4-6g Fish Oil/Day
Baby Aspirin
Eating Loads of Protein!
Nettle Caplets
Femoral Massage (Stop at ET)
Acupuncture (Stop at ET)
TCM Diet: No cold or slippery foods
Immune Friendly Diet: No non-sprouted wheat, sugar, starches. Little fruit.
No nightshades
No caffeine
No coffee, not even decaf
No soy when in cycle
10 days Doxycycline

Day of Transfer
Light activity

Post ET Changes
Visualization
200mg progesterone capsules
Take it easy days 2&3
No sex til beta#1
Cut out egg yolks (contains immunogenic acid)






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