2DP3DTFun with Resveratrol & IVF

I'm in the 2WW...not really feeling anxious except for one thing.

I was reading online today, trying to figure out if taking Resveratrol during early pregnancy was OK to do. Dr. Italian at the other clinic said to take it before a cycle but didn't say when to cease.

So this morning I popped my dex, my synthroid, and a 250mg pill of micronized Resveratrol. Then I pondered that I should ask Dr. Italian when I should stop taking the Resveratrol. I fired off an email to him and then continued to look online. Meanwhile, I found and read this research from The Chinese University of Hong Kong.

The abstract reads as such:

Estrogen is crucial in preparing of pregnancy, and its role in the maintenance of pregnancy has yet to be elucidated. During the course of pregnancy, the placenta is responsible for the provision of estrogen. The hormone biosynthesis is catalyzed by cytochrome P450 (CYP) 19 or aromatase. In the present study, we screened several common dietary components and identified the grape polyphenol resveratrol to be a potential inhibitor in the hormone synthesis. In a recombinant protein system resveratrol inhibited the aromatase activity with an IC50 value of not, vert, similar40 μM. Subsequent analysis was performed in the human placental JEG-3 cells, and 25 μM resveratrol significantly reduced the mRNA abundance in these cells. Since the transcriptional control of CYP19 gene is tissue-specific and the proximal promoter region of exon Ia has previously been shown to be crucial in CYP19 expression in placental cells, we also evaluated the promoter activity of this gene. Reporter gene assays revealed that resveratrol repressed the transcriptional control of promoter Ia. The present study illustrated the possibility that dietary supplementation of resveratrol interfered with the normal functioning of placental cells.

While I was reading the article above, Dr. Italian's first reply came back that I should just continue on until pregnant. I replied back immediately with the article link asking if I should be concerned. He didn't write back as fast as he replied the first time so I dashed off to the bathroom and yakked up my mornings meds just to be safe.

It wasn't until well after my breakfast and meds were flushed away that I realized that the article was about "placental" cells, not endometrial cells or embryos that haven't yet hatched. My 5 day old embryos are still encapsulated by the outer shell and won't hatch til tomorrow or the next day and even then I don't think they will have anything which one would refer to as placental cells. Wish this was something that we'd covered more deeply in college Anatomy/Physiology class. As I don't know the half-life of Resveratrol, I felt that yakking up my last pill was the safest thing I could do, just in case.

Stomach in a better mood, I retook my dex and synthroid - if the first dose was absorbed, I'm sure a double dose will do just fine. Nice way to start the day. I am going to hold off on taking anymore Resveratrol until Dr. Italian has had a chance to reply to my email. If he doesn't I will play it safe and abstain.