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Thursday, February 15, 2007

Sadness

A girlfriend of mine, MG (who isn't a blogger so I can only use initials to safeguard her privacy), just found out today, that she just lost her baby girl at 13 weeks. Her ultrasound was today and there was no movement and no heartbeat. It sounds like the amniotic fluid was on the low side and the doctor estimated that the baby had likely passed about a week ago.

MG had done CVS in the last few weeks and it had determined that her baby girl was chromosomally perfect. MG is an immune patient of Dr. B's and Dr. S's so she did the usual humira, lovenox, IVIg cocktail when she found out that she was pregnant.

Everything was fine. Fine until she did her CVS. Immediately prior to CVS her NKs were at about 22. Ultrasounds looked great. She had a SCH (subchorionic hemmorage) but it was handled effectively by cutting of her lovenox until it had subsided. Which it did. What is telling, however, is that after her CVS her NKs mysteriously skyrocketed to over 30. My take is on this that her CVS like introduced a uterine infection into the placental area that her body responded to with a full blown immune attack. We won't know for sure what happened until they are able to obtain a tissue sample for biopsy.

That CVS and amniocentesis can cause an infection that, in turn, can lead to miscarriage, scares the hell out of me. It's a strong arguement for doing PGD so that you can avoid having to do CVS or amnio at all. I think the risks for miscarriage due to CVS are something like 1 in 100. Maybe less. I remember when my friend Mary was pregnant last year, her NS showed her odds of a Down's baby were something like 1 in 300. The risk of miscarriage due to CVS was higher. 1 in 100 or thereabouts. They opted to not do an amnio or CVS due to the risk.

I thought they were being reckless. But you know, after hearing, tonight, about MG's loss, I really have to wonder if I will do CVS or amnio now. I'm not sure if we can afford to do PGD with each IVF. I doubt we can. But this really has opened my eyes to something I hadn't given much though to. Til now.

This was MG's second loss. The first came at 5 months and it was because her amnio showed DS. She terminated and she still lives with the torment of that decision. Today's loss was just another needle into her heart. And ours.

MG. I am so sorry for your loss. It's just utterly unfair.

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Ultrasound of a 9 week old fetus

Diagnosis:
elevated NKs, NKUs, 3 +APAs (2 borderline), heterozygous for MTHFR A1298C. Slightly low thyroid.

dq-α:
me: 1.1, 4.1
dh: 1.2, 3.1

Low LADs were treated in Mexico and elsewhere with LIT.
Anti-sperm antibodies
Article: LIT and the FDA

No: ANAs, normal TH1/TH2 Cytokine ratio, or x-DNA/Histones.

IF Treatments:
-Clomid #1: Sept 2005
-Clomid #2: Sept 2005
-HSG: Oct 2005
-Lap/Chromo: Oct 2005
-Nat'l IUI: Nov 2005
-IVF #1: Jan 2006, β1=2.0, β2=0.9
-IVF #2: May 2006, β1=<1.0
-Myomectomy (5), salpingectomy (both), & endo removed via lap on 6.6.6
-LIT#1 in Nogales: 6.16.6
-LIT#2: July 2006
-FET #1: Sept 2006, β1=2.48, β2=<2.0
-Dr. Hungarian Dx Oct 2006
-Dr. Hungarian Tx Dec 2006-Mar 2007
-IVF#3: Mar 2007 Canceled myself right before retrieval
-IVF#4: April/May 2007 Canceled due to dominant follicle
-IVF#4: August 2007, β1<2.0
-IVF#5: December 2007

Pre-ET
Feng Shui'd the House
500mg Zithromax starting with stims
4 LIT Treatments
17 Weeks of Humira or Enbrel
30g IVIg CD5 of IVF cycle (day 2 or 3 of stims)
30g IVIg 2 days before transfer
1mg Dexamethazone starting with stims
30mg Lovenox, 2X's/Day
0.0375mg Synthroid
Lexapro
Prenatal
Folguard 2.2 2x's/day
Extra 1g C (Stop at ET)
Extra 1g Calcium
Extra 400mg E (Stop at ET)
Nettle Tea & Capsules
2g Bromelain
Extra D3
Keep BMI<24
4-6g Fish Oil/Day
Baby Aspirin
Eating Loads of Protein!
Nettle Caplets
Femoral Massage (Stop at ET)
Acupuncture (Stop at ET)
TCM Diet: No cold or slippery foods
Immune Friendly Diet: No non-sprouted wheat, sugar, starches. Little fruit.
No nightshades
No caffeine
No coffee, not even decaf
No soy when in cycle
10 days Doxycycline

Day of Transfer
Light activity

Post ET Changes
Visualization
200mg progesterone capsules
Take it easy days 2&3
No sex til beta#1
Cut out egg yolks (contains immunogenic acid)






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